Professor Richard Flavell

Country: United States of America

Institution: Yale University

Research Areas: Study of Innate and Adaptive immunity, T cell tolerance and activation in immunity and autoimmunity, and regulation of T cell differentiation

Lab Website: https://medicine.yale.edu/immuno/people/richard_flavell.profile

Since 1980, my laboratory has used mouse reverse genetics to study innate and adaptive immunity, T cell tolerance, apoptosis and autoimmunity, and the regulation of T cell differentiation. Recent studies include the NLR family of innate sensors and their role in anti-infective responses and inflammatory disease. Most recently we have established the connection between inflammasomes, microbial homeostasis and chronic diseases. We have shown that dysbiosis of the microbiota leads to IBD and Metabolic Syndrome, including Obesity, Fatty Liver disease and Type 2 diabetes. For the past ten years, we have been developing and improving an entirely novel humanized mouse model capable of supporting engrafted human hematopoietic stem cells enabling generation of both adaptive and innate immune cells.