Associate Professor M. Anthony (Tony) Moody

Country: United States of America

Institution: Duke University, Durham, NC, USA

Research Areas: B cell biology, flow cytometry, detection of antigen-specific B cells, antibody maturation

Lab Website: https://dhvi.duke.edu/diseases-research/laboratories/b-cell-immunotechnology

The primary focus of the laboratory is the study of humoral responses to vaccination and infection with the goal of understanding how to elicit protective responses by vaccination. The laboratory develops antigen-specific reagents for the quantitation and isolation of B cells, and has active projects to study HIV-1, influenza, syphilis, and autoimmunity. The laboratory supports collaborative work for the Duke CHAVI-ID consortium as well as for several CAVD / Gates grants. The laboratory is a central resource for CHAVI-ID and DHVI for flow cytometry, including staining, phenotypic analysis, and sorting.

The laboratory is currently studying the evolution of B cell responses after HIV-1 infection and in collaboration with other DHVI and CHAVI-ID collaborators has been helping to establish the conditions that lead to the development of functional antibodies against HIV-1.

In addition, the laboratory is developing novel adjuvants for use in animal studies. This work has led to recent publications showing the ability of TLR-agonist combinations to boost immune responses to candidate HIV-1 immunogens.

The laboratory is also funded to study the response to influenza in humans and non-human primates, the bridging of Fc receptor biology between humans and rhesus macaques, and the immunity of syphilis.